Link proteins of basal lamina; consist of an A chain (400 kD) and two B chains (200 kD). Each subunit contains at least 12 repeats of the EGF-like domain. The first laminin studied was from mouse EHS cells, but it is now becoming clear that different forms of laminin occur. In laminin from placenta the A chain is replaced with merosin, in laminin found near the neuromuscular junction the B1 chain is replaced by s-laminin (synapse laminin). Laminin induces adhesion and spreading of many cell types and promotes the outgrowth of neurites in culture.
Lamanins are major proteins in the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion, as well as phenotype and survival. Laminins are trimeric pro...Found on http://en.wikipedia.org/wiki/Laminin
<protein> Link proteins of basal lamina, consist of an A chain (400 kD) and two B chains (200 kD). ... Each subunit contains at least 12 repeats of the EGF like domain. The first laminin studied was from mouse EHS cells, but it is now becoming clear that different forms of laminin occur. ... In laminin from placenta the A chain is replaced wi...Found on http://www.encyclo.co.uk/local/20973
an adhesive molecule of connective tissue related to fibronectin andtenascin.
Found on http://www.encyclo.co.uk/local/20169
Type: Term Pronunciation: lam′i-nin Definitions: 1. A large, multimeric glycoprotein component of the basement membrane, particularly the lamina lucida; it has binding sites for integrins, type IV collagen, and heparan sulfate. It is a major protein component of the lamina lucida of the renal glomerulus.Found on http://www.medilexicon.com/medicaldictionary.php?t=47886
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