(= hypoxanthine-guanine phosphoribosyl transferase) Enzyme that catalyses the first step in the pathway for salvage of the purines hypoxanthine and guanine. The phosphoribosyl moiety is transferred from an activated precursor, 5-phosphoribosyl 1-pyrophosphate. Since animal cells can synthesize purines de novo , HGPRT-mutants can be selected by their resistance to toxic purine analogues. A genetic lesion in HGPRT in humans underlies the Lesch-Nyhan syndrome. See HAT medium.
Synonym for hypoxanthine-guanine phosphoribosyl transferase ... <enzyme> An enzyme which plays an important role in the making of ATP and GTP from guanine -- the only way guanine, adenine, or other purine molecules are able to become part of nucleic acids. Biologists study gene action via the incorporation of modified nitrogenous bases into D...Found on http://www.encyclo.co.uk/local/20973
Type: Abbreviation Definitions: 1. Abbreviation for hypoxanthine guanine phosphoribosyltransferase.Found on http://www.medilexicon.com/medicaldictionary.php?t=40920
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