
Filaggrin is a filament-associated protein that binds to keratin fibers in epithelial cells. == Profilaggrin == Filaggrin monomers are tandemly clustered into a large, 350kDa protein precursor known as profilaggrin. In the epidermis, these structures are present in the keratohyalin granules in cells of the stratum granulosum. Profilaggrin undergoe...
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http://en.wikipedia.org/wiki/Filaggrin

<molecular biology> Basic protein components of keratohyalin granules of the suprabasal cells of the skin. ... Family of intermediate filament associated cationic proteins found in mammalian epidermis. Bundle cytokeratin filaments. Various sizes in different species (16 kD bovine, 26 kD mouse, 35 kD man, 45 kD rat). ... (10 Mar 1998) ...
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http://www.encyclo.co.uk/local/20973

Type: Term Pronunciation: fil-ag′grin Definitions: 1. A major protein of the keratohyalin granule, composed mostly of l-histidyl, l-lysyl, and l-arginyl residues (stratum corneum basic proteins). It aggregates keratin intermediate filaments and promotes disulfide bond formation.
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http://www.medilexicon.com/medicaldictionary.php?t=33294
noun the main protein of the keratohyalin granules; `the specific target of the immune response in rheumatoid arthritis is filaggrin`
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https://www.encyclo.co.uk/local/20974
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