Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated N...
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<protein> Calmodulin stimulated protein phosphatase (EC 3.1.3.16), the major calmodulin binding protein in brain. ... Enzymic activity is inhibited by binding of immunophilin ligand complex (immunophilin alone does not bind) and therefore may play a part in the mechanism of action of cyclosporin A and FK506. Thought also to be involved in the...
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Calmodulin-stimulated protein-phosphatase (EC 3.1.3.16) , the major calmodulin-binding protein in brain. Enzymic activity is inhibited by binding of immunophilin-ligand complex (immunophilin alone does not bind) and therefore may play a part in the mechanism of action of cyclosporin A and FK506. Thought also to be involved in the control of sperm motility.
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Type: Term Pronunciation: kal′sē-nyūr′in Definitions: 1. A calcium-dependent serine-threonine phosphatase involved in T-cell signaling transcription; the target of cyclosporine immunosuppression; the reaction cascade in which it resides is referred to as the calcineurin pathway.
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