(= Bruton&`s tyrosine kinase) Tyrosine kinase of tec family, defective in Bruton&`s agammaglobulinaemia. Mutations in btk lead to B-cell immunodeficiencies XLA in humans, Xid in mice. Overexpression of btk enhances calcium influx following B-cell antigen receptor crosslinking. Sab selectively binds the SH3 domain of btk. Btk interacts with membrane through PH domain, and SHIP, by reducing PIP3 levels, regulates this association.
Type: Abbreviation Definitions: 1. Abbreviation for Bruton tyrosine kinase.Found on http://www.medilexicon.com/medicaldictionary.php?t=12603
No exact match found