btk

(= Bruton&`s tyrosine kinase) Tyrosine kinase of tec family, defective in Bruton&`s agammaglobulinaemia. Mutations in btk lead to B-cell immunodeficiencies XLA in humans, Xid in mice. Overexpression of btk enhances calcium influx following B-cell antigen receptor crosslinking. Sab selectively binds the SH3 domain of btk. Btk interacts with membrane through PH domain, and SHIP, by reducing PIP3 levels, regulates this association. ...

Btk

Type: Abbreviation Definitions: 1. Abbreviation for Bruton tyrosine kinase.
Found on http://www.medilexicon.com/medicaldictionary.php?t=12603
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