Anti-tumour drug (a poly-hydroxylated alkatetraene lactone) that, like taxol, promotes formation of stable bundles of microtubules and competes with taxol for binding to polymerized tubulin. Isolated from the marine sponge, Discodermia dissoluta .


(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea marine sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR can...
Found on http://en.wikipedia.org/wiki/Discodermolide
No exact match found