Angiopoetin-1 (498 residues) is the ligand for Tie2; angiopoietin-2 (496 residues) is a natural antagonist. Angiopoietin-1, but not Ang-2, is chemotactic for endothelial cells: neither have effects on proliferation.


Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood cells. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, ...
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