1) Soothe 2) To make less irritable 
to alleviate irritation; to reduce sensitivity
• (v. t.) To diminish the sensibility of; to debilitate.
Ab·ir'ri·tate transitive verb [ Prefix ab- + irritate .] (Medicine) To diminish the sensibility of; to debilitate. 
abirritate 1. To diminish the sensibility of; to debilitate. 2. To make less irritable; to soothe.
to make less irritable; soothe.