
1) Ancestor of poker 2) Card game of the 1600s 3) Comparing card game 4) First, for Felipe 5) First, to Francisco 6) River of South America 7) River in The Americas 8) River in The New World 9) River in Chile 10) River in South America 11) River of The Americas 12) River of Chile
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https://www.crosswordclues.com/clue/primero

1) Uno
Found on
https://www.crosswordclues.com/clue/primero

Primero, Prime, Primus, Primiera, Primavista, often referred to as `Poker’s mother”, as it is the first confirmed version of a game directly related to modern day poker, is a 16th-century gambling card game of which the earliest reference dates back to 1526. The game of Primero is closely related to the game of Primo visto, if not the same. .....
Found on
http://en.wikipedia.org/wiki/Primero

• (n.) A game at cards, now unknown.
Found on
http://thinkexist.com/dictionary/meaning/primero/
Pri·me'ro noun [ Spanish
primera , from
primero first, from Latin
primarius . See
Premier .] A game at cards, now unknown.
Shak. Found on
http://www.encyclo.co.uk/webster/P/161

Primero is an old Italian card game which became popular throughout Europe in the 16th century and perhaps earlier. It is a showdown game in which players are dealt four cards. The combination which gives its name to the game is the prime, which consists of one card of each suit.
Found on
http://www.probertencyclopaedia.com/browse/OP.HTM

a card game fashionable in England in the 16th and 17th centuries.
Found on
https://www.infoplease.com/dictionary/primero
No exact match found.