
Alloxan (2,4,5,6-pyrimidinetetrone) is an oxygenated pyrimidine derivative. It is present as alloxan hydrate in aqueous solution. ==History== Alloxan was originally isolated in 1818 by Brugnatelli and was named in 1838 by Wöhler and Liebig. The name `Alloxan` emerged from an amalgamation of the words `allantoin` and `Oxalsäure` (oxalic aci...
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• (n.) An oxidation product of uric acid. It is of a pale reddish color, readily soluble in water or alcohol.
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<chemical> Used to produce diabetes mellitus in experimental animals. Destroys beta cells in the pancreas by a mechanism involving superoxide production. ... (15 Nov 1997) ...
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(ә-lok´san) an oxidized product of uric acid that tends to destroy the islet cells of the pancreas, thus producing diabetes mellitus. It has been obtained from intestinal mucus in diarrhea and has been used in nutrition experiments and as an antineoplastic agent.
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Used to produce diabetes mellitus in experimental animals. Destroys B cells in the pancreas by a mechanism involving superoxide production.
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Al·lox'an noun [
All antoin +
oxa lic, as containing the elements of
allantion and
oxalic acid.]
(Chemistry) An oxidation product of uric acid. It is of a pale reddish color, readily soluble in water or alcohol.
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Type: Term Pronunciation: ă-loks′-an Definitions: 1. An oxidation product of uric acid, 2,4,5,6-pyrimidinetetrone; administration to experimental animals causes hypoglycemia resulting from insulin liberation, followed by hyperglycemia resulting from destruction of the islets of Langerhans (alloxan diabetes).
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a white crystalline pyrimidine derivative, CHON, used in biomedical research to induce diabetes in laboratory animals.
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