vicissitude, vicissitudes 1. A change or variation. 2. The quality of being changeable; mutability. 3. One of the abrupt or unexpected changes or shifts often met with in one's life, activities, or surroundings. Found on http://www.wordinfo.info/words/index/info/view_unit/2297/
1) Ups and downs 
vicissitude, vicissitudes 1. A change or variation. 2. The quality of being changeable; mutability. 3. One of the abrupt or unexpected changes or shifts often met with in one's life, activities, or surroundings.