1) Affect drastically 2) Affect radically 3) Beat; defeat 4) Become turned or set on end 5) Capsize 6) Cause to capsize 7) Cause to topple over 8) Cheerful conclusion 9) Defeat 10) Drastically affect 11) Flip 12) Flip head over heels 13) Flip over 14) Invert 15) Knock for a loop 16) Knock off balance Found on https://www.crosswordclues.com/clue/upend
to set on end, as a barrel or ship. · to affect drastically or radically, as tastes, opinions, reputations, or systems. · to defeat in competition, as in boxing or business. Found on https://www.infoplease.com/dictionary/upend