1) Cumbersomeness 2) Unwieldiness 3) Worriment 
[n] - a difficulty that causes anxiety
troublesome, troublesomely, troublesomeness 1. Difficult to deal with. 2. Causing difficulties or taking a great deal of time. 3. producing annoyance, discomfort, or anxiety, especially in a recurrent way; such as, having a troublesome knee or a hip pain.'
inconvenience 1 worriment noun a difficulty that causes anxiety