Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and Phosphatidylinositol (4,5)-bisphosphate(PIP2). It belongs to family of 5-phosphatases, which are structurally unrelated to D...
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http://en.wikipedia.org/wiki/Synaptojanin
Protein of the vertebrate nerve terminal (145 kD) that seems to participate with dynamin in the process of vesicle recycling. Has phosphatase activity and is a member of the inositol-5-phosphatase family. Amino-terminal region has homology with yeast Sac1 (involved in phospholipid metabolism) and C-terminal region has proline-rich sequences that probably interact with SH3 domains of amphiphysin and GRB-2.
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http://www.encyclo.co.uk/visitor-contributions.php
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