1) Eliminated rough edges 2) Ironed 3) Made smooth by ironing 4) Smoothed 1) Ironed 2) Smoothed 
Smoothened is a G protein-coupled receptor protein encoded by the {gene|SMO} gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to ...