Multi-pass transmembrane proteins, PS1 and PS2, found in Golgi. Mutations in genes for PS1 are associated with 25% of early onset Alzheimer's disease and altered amyloid b protein <28>S b -amyloid precursor protein) processing. PS1 is a functional homologue of SEL-12, a protein found in Caenorhabditis elegans that facilitates signalling mediated by Notch, and the expression of PS1 seems to be essential for the spatio-temporal expression of Notch1 and Dll1 (Delta-like gene 1) during embryogenesis. PS1 and PS2 are also similar to C. elegans Spe-1 , a gene involved in protein trafficking in the Golgi during spermatogenesis.
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Found on
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Genes, mutations of which are linked to early-onset Alzheimers disease.
Found on
https://www.encyclo.co.uk/local/23246
No exact match found.
