plaguey 1. Something that is likely to spread and cause an epidemic disease; plaguey fevers; pestilent, pestilential, pestiferous. 2. Causing irritation or annoyance; 'tapping an annoying rhythm on his glass with his fork'; 'aircraft noise is particularly bothersome near the airport'; 'found it galling to have to ask permission'; 'an irritating de... Found on http://www.wordinfo.info/words/index/info/view_unit/3360/