plagiocephaly, plagiocephalism 1. A deformity of the skull in which one side is more developed in the front, and the other side is more developed in the rear. 2. A malformation of the skull producing the appearance of a twisted and lopsided head, caused by irregular closures of the cranial sutures. Found on http://www.wordinfo.info/words/index/info/view_unit/1685/