Paraoxonases are a group of enzymes involved in the hydrolysis of organophosphates and lactones. ==History== PON was identified as an enzyme having organophosphates as its substrates. Reports of the geographic differences in population frequencies of paraoxonase activity and genetic analysis led to uncovering the genetic polymorphism. ==Types== Th...
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http://en.wikipedia.org/wiki/Paraoxonase
(= PON1) Human serum protein (45 kD glycoprotein) located on high density lipoprotein (HDL) and that has been implicated in detoxification of organophosphates and possibly preventing the oxidation of LDL. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and to atherosclerosis.
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: par-ă-oks′ŏ-nās Definitions: 1. A high-density-lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, with a known polymorphism; aryldialkylphosphatase, E.C.3.1.8.1. Two isoforms occur: A isoform, with glutamine at position 192; B isoform, with arginine at position 192.
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http://www.medilexicon.com/medicaldictionary.php?t=65201
Paraoxonase: An enzyme associated with high-density lipoprotein (HDL) that is believed to protect against the oxidation of low-density lipoprotein (LDL) and hence to affect the risk of coronary artery disease. There are 3 paraoxonase genes (PON1, PON2 and PON3) all of which are clustered in the same region on chromosome 7. The severity of coronary ...
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http://www.medterms.com/script/main/art.asp?articlekey=22190
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