1) Ache cause 2) Cause of depletion 3) Cause of diminishing returns 4) Cause of jading 5) Cause to become a cliché 6) Deplete 7) Development 8) Do to death 9) Employ excessively 10) Employ to excess 11) Employ too often 12) Excessive application 13) Excessive employment 14) Exploitation 15) Make hackneyed Found on https://www.crosswordclues.com/clue/overuse