1) DCCC times II 2) End of the 14th century 3) Fast-food giant, on Wall St 4) Hosted an event 5) II PM 6) Last year of the 14th century 7) Played host 8) Roman 1,400 9) XL times XXXV 10) XXXV x XL 11) Year chaucer died 12) Year that chaucer died Found on https://www.crosswordclues.com/clue/mcd
MCD: Abbreviation (not only for McDonald's but also) for a number of entities in medicine including minimal change disease, mean corpuscular diameter, and medullary cystic disease. Found on http://www.medterms.com/script/main/art.asp?articlekey=24096