Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin heavy chains. This disease is characterized by an excessive production of heavy chains that are short and truncated. These heavy chain disease proteins have various deletions, mainly in their amino-terminal part, which causes the heavy chains to...
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http://en.wikipedia.org/wiki/Heavy_chain_disease
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the n- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cr...
Found on
http://www.encyclo.co.uk/local/20973
Type: Term Definitions: 1. a term used for a group of diseases, the paraproteinemias, characterized by production of homogeneous immunoglobulins or fragments, and associated with malignant disorders of the plasmacytic and lymphoid cell series. Three types have been recognized: γ-heavy-chain disease, α-heavy-chain disease, and μ-heavy...
Found on
http://www.medilexicon.com/medicaldictionary.php?t=25539
No exact match found.
