Grammotoxin is a toxin in the venom of the tarantula Grammostola spatulata. It is a protein toxin that inhibits P-, Q- and N-type voltage-gated calcium channels (Ca 2+ channels) in neurons. Grammotoxin is also known as omega-grammotoxin SIA. == Chemistry == Grammotoxin is a 36 Amino Acid protein toxin, which has the following sequence: Asp-Cys-Val...
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(= w-grammotoxin SIA) Toxin (peptide, 36 residues) from spider, Grammostola spatulata , that inhibits non-L-type voltage-regulated calcium channels, thus resembling w -conotoxins and w -agatoxins. See VSCC.
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