β-Glucocerebrosidase (also called acid β-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, or GCase) is an enzyme with glucosylceramidase activity ({EC number|3.2.1.45}) that is needed to cleave, by hydrolysis, the beta-glucosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism. It is localized in the l...
Found on
http://en.wikipedia.org/wiki/Glucocerebrosidase
(from the article `Gaucher disease`) ...autosomal recessive trait and is caused by one or more mutations in a gene called acid beta-glucosidase (GBA). These mutations result in defects ... In Gaucher`s disease, abnormal amounts of cerebrosides accumulate in the liver, spleen, bone marrow, and lymph nodes. The defective enzyme is ... ...
Found on
http://www.britannica.com/eb/a-z/g/39
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