Familial hypercholesterolemia (abbreviated FH, also spelled familial hypercholesterolaemia) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, `bad cholesterol`), in the blood and early cardiovascular disease. The high cholesterol levels in FH are less responsive to the .....
(from the article `metabolic disease`) Familial hypercholesterolemia is an autosomal dominant disease that is caused by the deficiency of the LDL receptor on the surface of cells in the ... ...and vessel damage. Particularly vulnerable to premature CHD are middle-aged men, especially those with a family history of the disease, and ... ...
Excess of cholesterol in plasma as a result of defects in the recycling process that leads to reduced uptake of LDL (low density lipoprotein) into coated vesicles.
Type: Term See: familial hyperlipoproteinemia type II
Familial hypercholesterolemia: The most common inherited type of hyperlipidemia (high lipid levels in blood). One in every 500 children is born with familial hypercholesterolemia. The condition predisposes to premature arteriosclerosis including coronary artery disease with heart attacks at an unusually young age. Persons with familial hypercholest...
[n] - congenital disorder characterized by high levels of cholesterol and early development of atherosclerosis
noun congenital disorder characterized by high levels of cholesterol and early development of atherosclerosis
A genetic predisposition to dangerously high cholesterol levels.