Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic ...
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http://en.wikipedia.org/wiki/Excitotoxicity
Pathological process by which neurons are damaged and killed by the overactivation of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and AMPA receptor. Note: Excitotoxins like NMDA and kainic acid bind to glutamate t receptors, and can cause excitotoxicity by allowing high levels of calcium ions to enter cells, a...
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http://sis.nlm.nih.gov/enviro/iupacglossary/glossarye.html
Type: Term Pronunciation: ek-sī′tō-tok-sis′i-tē Definitions: 1. Neuronal death resulting from increased intracellular glutamate; neuronal ischemia leads to ATP loss and depolarization, with glutamate release from synapses, and subsequent overstimulation leading to sodium and calcium ion gate porosity.
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http://www.medilexicon.com/medicaldictionary.php?t=30901
The over-stimulation of nerve cells by nerve impulses. Excitotoxicity often leads to cell damage or cell death.
Found on
https://www.encyclo.co.uk/local/23246
No exact match found.
