Endostatin is a naturally-occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth fa...
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http://en.wikipedia.org/wiki/Endostatin
A substance being studied in the treatment of cancer. Endostatin is made from a type of collagen (a protein found in cartilage and other connective tissue). It may prevent the growth of new blood vessels that tumors need to grow. Endostatin is a type of antiangiogenesis agent. Also called COL18A1.
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http://www.cancer.gov/dictionary?expand=E
Type: Term Pronunciation: en′dō-stat-in Definitions: 1. An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine k...
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http://www.medilexicon.com/medicaldictionary.php?t=29198
Endostatin: Endostatin is a piece (a fragment) of a protein, collagen 18, found in all blood vessels. This fragment is normally secreted by tumors. It appears to halt the process of developing new blood vessels (angiogenesis) which is necessary to tumor development. Endostatin may, it is hoped, represent a prototype for a new class of agents with w...
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http://www.medterms.com/script/main/art.asp?articlekey=6523
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