Cubilin is a protein that in humans is encoded by the CUBN gene. == Function == Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive...
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Type: Term Pronunciation: kyūb′i-lin Definitions: 1. a receptor expressed in the apical endocytic apparatus of the renal proximal tubular epithelial cells and in gastrointestinal epithelium. In the gastrointestinal tract it is also referred to as intestinal intrinsic factor-cobalamin receptor. Cubilin is colocalized with megalin in the r...
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