(= Shp-1, Shp-2) Protein tyrosine phosphatases with SH2 domains. Are recruited to ITIM motif of receptor tyrosine kinases and play an important role in the control of cytokine signalling. Shp-1 is important in regulating antigen responses in T-cells and the mouse mutant ( motheaten ) is immunosuppressed. Shp-2 is more ubiquitously expressed and functions downstream of a variety of growth factor receptors and has a role in cell spreading and migration; the homozygous mouse knockout is embryonic lethal.
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