1) Annoys 2) Frills 3) Irks 4) Nettles 5) Riles 6) Tees off 1) Irritates 2) Low drumrolls 3) Slang for handcuffs 
Ruffles is the name of a brand of ruffled (crinkle-cut) potato chips produced by Lay`s potato chips, a division of Frito-Lay. The Frito Company acquired the rights to Ruffles brand potato chips in 1958. It later merged with H.W. Lay & Co. in 1961. The product is named as an analogy to the ruffle, a strip of fabric sometimes gathered, creating fol....
Slender projections of the exterior surface of a dicyemid mesozoan.Projections at the leading edge of a crawling cell. In time lapse films the active edge appears to ‘ruffle`. The protrusions are apparently supported by a microfilament meshwork, and can move centripetally over the dorsal surface of a cell in culture.
Ruffles is slang for handcuffs.