1) General anesthetic 
Renanolone (INN) is a semisynthetic neuroactive steroid that was described as a general anesthetic, but was never developed for clinical use. Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABAA receptor, a property which is almost certain to be the case for renan...