Oncoprotein (95 kD) that binds to p53 and negatively regulates its transcriptional activity.
Oncoprotein that inhibits p53 by binding to the transcriptional activator domain of p53 preventing it from regulating its target genes. Mdm2 expression is activated by p53 and Mdm2 promotes degradation of p53 by the proteasome - a complex feedback regulation.