1) Start of a loyalty oath 
The iPLEDGE program is a mandatory distribution program in the United States for isotretinoin (commonly sold under the trade names Claravis, Absorica, Amnesteem, Myorisan, Sotret or Zenatane), intended to prevent the use of the drug during pregnancy due to the high risk of birth defects (see Teratogenicity of isoretinoin). As of March 1, 2006, pat...