Haploinsufficiency occurs when a diploid organism has only a single functional copy of a gene (with the other copy inactivated by mutation) and the single functional copy does not produce enough of a gene product (typically a protein) to bring about a wild-type condition, leading to an abnormal or diseased state. It is responsible for some but not...
Found on
http://en.wikipedia.org/wiki/Haploinsufficiency
A situation in which the protein produced by a single copy of an otherwise normal gene is not sufficient to assure normal function.
Found on
http://www.daviddarling.info/encyclopedia/H/haploinsufficiency.html
Haploinsufficiency: A situation in which the total level of a gene product (a particular protein) produced by the cell is about half of the normal level and that is not sufficient to permit the cell to function normally. Another way to define haploinsufficiency is as a condition that arises when the normal phenotype requires the protein product of ...
Found on
http://www.medterms.com/script/main/art.asp?articlekey=18474
No exact match found.
