First pass effect definitions

First pass effect

The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall. Notable dr...
Found on http://en.wikipedia.org/wiki/First_pass_effect

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first-pass effect

(from the article `poison`) ...in the gastrointestinal tract must pass through the liver, where they can be biotransformed and thus eliminated before being distributed to other ...
Found on http://www.britannica.com/eb/a-z/f/29

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First-pass effect

Biotransformation of a xenobiotic before it reaches the systemic circulation. The biotransformation of an intestinally absorbed xenobiotic by the liver is referred to as a hepatic first-pass effect.
Found on http://www.encyclo.co.uk/visitor-contributions.php

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First-pass effect

This is the chemical alteration resulting from biotransformation of a xenobiotic before it reaches the systemic circulation. Such biotransformation by the liver is referred to as a hepatic first-pass effect.
Found on http://www.encyclo.co.uk/visitor-contributions.php

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first-pass effect

Type: Term Synonyms: first-pass metabolism
Found on http://www.medilexicon.com/medicaldictionary.php?t=28017

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