1) Disease 
• (n.) Perturbation of mind; mental uneasiness. • (n.) Disorder of body; slight illness; distemper. • (n.) Bad temperature; intemperateness; excess of heat or cold, or of other qualities; as, the distemperature of the air. • (n.) Disorder; confusion.
Dis·tem'per·a·ture noun 1. Bad temperature; intemperateness; excess of heat or cold, or of other qualities; as, the distemperature of the air. [ Obsolete] 2. Disorder; confusion. Shak. 3. Disorder of body; slight illness; distemper. « A huge infectious ...
a distempered or disordered condition; disturbance of health, mind, or temper.