The Crowe sign or Crowe`s sign is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen`s disease). These freckles occur in up to 30% of people with the disease and their presence is one of seven diagnostic criteria for neurofibromatosis. Freckles can also be present in the intertriginous area in..... Found on http://en.wikipedia.org/wiki/Crowe_sign