Comedones: The plural of comedo, the primary sign of acne, consisting of a dilated (widened) hair follicle filled with keratin squamae (skin debris), bacteria, and sebum (oil). Comedones may be closed or open. A closed comedo has an obstructed opening to the skin and may rupture to cause a low-grade skin inflammatory reaction in the area. The commo... Found on http://www.medterms.com/script/main/art.asp?articlekey=10437