CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose ...
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http://en.wikipedia.org/wiki/CREB
Cyclic AMP response element binding factor. Basic leucine zipper (bZip) transcription factor involved in activating genes through cAMP; binds to CRE element TGANNTCA. Phosphorylation by cAMP-dependent protein kinase (PKA) at serine-119 is required for interaction with DNA and phosphorylation at serine-133 allows CREB to interact with CBP (CREB binding protein) leading to interaction with RNA polymerase II.
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http://www.encyclo.co.uk/visitor-contributions.php
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