The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leadi...
Found on
http://en.wikipedia.org/wiki/Apoptosome
Type: Term Pronunciation: ă-pop′tō-sōm Definitions: 1. A heptameric apoptotic protease activating factor 1 (Apaf-1)-cytochrome-c complex. The apoptosome recruits and activates caspases that cleave intracellular substrates and ultimately lead to cell death by apoptosis. Release of mitochondrial cytochrome-c into the cytoplasm re...
Found on
http://www.medilexicon.com/medicaldictionary.php?t=5613
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