leproma, lepromatou 1. A cutaneous (skin) nodule or tubercle characteristic of leprosy. 2. A superficial granulomatous nodule rich in Mycobacterium leprae, and the characteristic lesion of lepromatous leprosy. 3. A fairly well-circumscribed discrete focus of granulomatous inflammation, caused by Mycobacterium leprae, which consists chiefly of an ...