Hepoxilins (HxA3 and HxB3) are nonclassic eicosanoid hormones involved in inflammation. ==History== Hepoxilins were identified and named in Canada in 1984 by CR Pace-Asciak and JM Martin. ==Biochemistry== They derive from arachidonic acid via oxidation by the enzyme 12-lipoxygenase. Hepoxilins are differentiated from closely related eicosanoids, t...