
1) Having the best hands 2) Least diffident 3) Least doubtful 4) Least dubious 5) Least equivocal 6) Least iffy 7) Least in question 8) Least tentative 9) Least vacillating 10) Like the risk to bet on 11) Maximally convinced 12) Most certain 13) Most confident 14) Most convinced 15) Most definite 16) Most indisputable
Found on
https://www.crosswordclues.com/clue/surest
No exact match found.