Tyrosine kinase (72 kD), an effector of the B-cell receptor signalling pathway. Contains two tandem SH2 domains through which it interacts with ITAM motif. More widely distributed than zap70 and important in signalling in both myeloid and lymphoid cells.


Spleen tyrosine kinase, also known as Syk, is an enzyme which in humans is encoded by the SYK gene. == Function == SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain. While Syk and Zap-70 are primarily express...
Found on
No exact match found