(= insulin receptor substrate-1) Multi-site docking protein (180 kD) that is phosphorylated by insulin and IGF-1 receptors following ligand binding. The tyrosine-phosphorylated form of irs-1 will interact with the SH2 domains of p85 of PI-3-kinase, Grb2 and PTP-2.
Type: Abbreviation Definitions: 1. Abbreviation for insulin receptor substrate-1.Found on http://www.medilexicon.com/medicaldictionary.php?t=45756
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