gab-1

(= Grb2-associated binder-1) Protein, 77 kD, 694 residues, that binds to Grb-2 and has homology with IRS-1 (insulin receptor substrate-1), particularly in the PH domain in the N-terminal region. Gab-1 is a substrate for the EGF-receptor and may integrate signals from different receptors into the control of cellular responses: overexpression of Gab-1 makes cells more responsive to limiting amounts of growth factors. Gab-1 is found in most human tissues. ...
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