Oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven 'ankyrin-repeats' very similar to those found in I k B. Seems to interfere with binding of 50 kD subunit of NF k B to DNA.
Synonym for bcl ... <oncogene> Two variants of this oncogene are recognised. ... 1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9. ... See: ced mutant...Found on http://www.encyclo.co.uk/local/20973
No exact match found