Group of calcium-binding proteins that interact with acidic membrane phospholipids in membranes. They contain 4 or 8 repeats of a 61-amino acid domain that folds into 5 a -helices. Also known by several other names (eg. lipocortins, endonexins), reflecting the history of their discovery in different contexts. See Table A3, lipocortin, endonexin I and II, calpactin, p70, and calelectrin.
Annexins: The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids. The antiphospholipid antibody syndrome is due to a deficiency of annexin V. Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (cl...Found on http://www.medterms.com/script/main/art.asp?articlekey=8971
Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70 kD repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in membrane fusion and signal transduction. ... (12 Dec...Found on http://www.encyclo.co.uk/local/20973
Type: Term Pronunciation: a-nek′sinz Definitions: 1. A family of at least 13 Ca2+-dependent phospholipid-binding proteins that may act as mediators of intracellular calcium signals.Found on http://www.medilexicon.com/medicaldictionary.php?t=4389
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