VacA

(= vacuolating cytotoxin) Protein (600-700 kD: hexamers or heptamers of identical 140 kD monomers) released into culture supernatant by Type I Helicobacter pylori > Helicobacter pylori. The 140 kD precursor is cleaved to form a 95 kD VacA monomer which is further cleaved to produce 37 and 58 kD fragments that behave as an AB toxin. Causes formation of large vacuoles in epithelial cells. ...
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