Could be considered an isolated epitope: although a hapten (by definition) has an antibody directed against it, the hapten alone will not induce an immune response if injected into an animal, it must be conjugated to a carrier (usually a protein). The hapten constitutes a single antigenic determinant; perhaps the best known example is dinitro-phenol (DNP) that can be conjugated to BSA and against which anti-DNP antibodies are produced (antibodies to the BSA can be adsorbed out). Because the hapten is monovalent, immune complex formation will be blocked if the soluble hapten is present as well as the hapten-carrier conjugate (assuming there is more than one hapten per carrier then an immune precipitate can be formed). Competitive inhibition by the soluble small molecule is sometimes referred to as haptenic inhibition, and this term has carried over into lectin-mediated haemagglutination where monosaccharides are added to try to block haemagglutination: the blocking sugar defines the specificity of the lectin.
A hapten is a low molecular weight molecule that contains an antigenic determinant but which is not itself antigenic unless combined with an antigenic carrier.Found on http://www.chem.qmul.ac.uk/iupac/medchem/ah.html
Hapten: In immunology, a molecule that is incapable, alone, of causing the production of antibodies but which can do so when fastened to a larger antigenic molecule called a carrier. The term 'hapten' was taken from the Greek verb 'haptein' meaning 'to fasten or bind.' Haptin and haptene are alternative forms of this term that was first introduced ...Found on http://www.medterms.com/script/main/art.asp?articlekey=15330
<immunology, molecular biology> Could be considered an isolated epitope: although a hapten (by definition) has an antibody directed against it, the hapten alone will not induce an immune response if injected into an animal, it must be conjugated to a carrier (usually a protein). ... The hapten constitutes a single antigenic determinant, perha...Found on http://www.encyclo.co.uk/local/20973
(hap´tәn) a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapte...Found on http://www.encyclo.co.uk/local/21001
small molecule that stimulates the production of antibody molecules only when conjugated to a larger molecule, called a carrier molecule.[1 related articles]Found on http://www.britannica.com/eb/a-z/h/15
hapten In immunology, a small molecule, having at least one of the determinant groups of an antigen, that can combine with an antibody but is not immunogenic unless it acts in conjunction with a carrier molecule.Found on http://www.wordinfo.info/words/index/info/view_unit/954/
A compound, usually of low molecular weight, that is not itself immunogenic but that, after conjugation to a carrier protein or cells, becomes immunogenic and induces antibody, which can bind the hapten alone in the absence of carrier.
Found on http://www.encyclo.co.uk/local/21016
Type: Term Pronunciation: hap′-ten Definitions: 1. A molecule that is incapable, by itself, of causing a cell-mediated or humoral immune response but can, however, combine with a larger antigenic molecule called a carrier. A hapten-carrier complex can stimulate antibody production and reactive T-cells. Synonyms: incomplete antigen, partial an...Found on http://www.medilexicon.com/medicaldictionary.php?t=39240
A hapten is a low molecular weight molecule that contains an antigenic determinant but which is not itself antigenic unless combined with an antigenic carrier.Found on http://www.chemistry-dictionary.com/definition/hapten.php
A hapten is a small molecule that can elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself. (In general, only large molecules, infectious agents, or insoluble foreign matter can elicit an immune response in the body.) Once the body has gener...Found on http://en.wikipedia.org/wiki/Hapten
A substance that becomes antigenic when it complexes with proteins.Found on http://www.vetmed.wsu.edu/glossary/glossary.asp
A low-molecular-weight molecule that is recognized by preformed antibody but is not itself immunogenic unless conjugated to a `carrier” molecule that provides epitopes recognized by helper T-cells.Found on http://www.roitt.com/glossary.asp
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